We are seeking a motivated and driven postdoctoral research fellow to join the Programme in Translational and Clinical Liver Cancer Research at the National Cancer Centre Singapore (PI: Prof Pierce Chow*) This multidisciplinary, whole-of-nation program addresses knowledge gaps in Liver Cancer across translational research to randomized controlled trials. The candidate will leverage on data and insights from multiple -omics platforms to conduct investigations addressing the molecular mechanisms underpinning hepato-carcinogenesis of hepatocellular carcinoma especially the role of bile acid in the and the relationship to metabolic liver disease. The successful candidate will identify potential leads from patient profiling data, lead experimental validations, and contribute to mechanistic understanding of bile acid dysregulation on HCC development. The candidate will assist the Principal Investigator in the conceptualization and execution of research projects, coordinate bile acid-focused studies within multidisciplinary investigations, and lead grant applications and manuscript preparation. The successful candidate will thrive in a dynamic and collaborative research environment, working closely with bioinformaticians, clinicians, and researchers involved in ongoing clinical trials. This role offers a unique opportunity to contribute to cutting-edge cancer biology research, with the potential to directly impact population health in HCC.
*tenured Professor at Duke-NUS Medical School; NMRC STaR investigator.
Your responsibilites will include:
Research Design & Experimental Execution
- Design and execute experiments to answer translational research question to impact population health.
- Collaborate with investigators across disciplines, including cancer biology, metabolomics and microbiome research, immunology, and clinical hepatology.
Data Analysis & Interpretation
- Analyze experimental results and draw meaningful conclusions.
- Present findings to stakeholders and team members effectively.
Publication and grant application
- Lead publication and grant application efforts alongside PI.
Requirements:
- PhD in Biochemistry, Microbiology, Molecular Biology, or related discipline.
- Experience with the following is essential:
- Flow cytometry, ELISA, immunoprecipitation and/or immunohistochemistry.
- Cell culture and molecular biology techniques (e.g., Western blot, DNA/RNA extraction, qPCR, PCR, gel electrophoresis, and cell-based assays).
- Animal models, especially germ-free or humanised mouse models.
- Microbiology or host–microbe interaction research, ideally with relevance to cancer, liver diseases, or inflammation.
- Knowledge in bile acid research will be an advantage.
- Strong desire in publishing high impact factor papers and applying for grant.
- Possess excellent analytical, technical and problem-solving skills.
- Well organized and detail oriented.
- Ability to coordinate diverse groups of people.
- Excellent written and verbal communication skills.
- Able to work independently and interactively in a team setting, motivated, responsible and a fast learner.
